The production and distribution of bibles are issues that have engaged the attention of Christian leaders for centuries. In an extant letter, dated 331, Emperor Constantine requested Eusebius, bishop of Caesarea, to provide him with fifty copies of the Old and New Testaments for use in the principal churches in Constantinople. In 797, Charlemagne commissioned Alcuin to prepare an emended text of the Vulgate; multiple copies of this text were created, not always accurately, in the famous writing schools at Tours.
The first book printed in Europe was the Latin Bible, and Copinger estimates that 124 editions of the Vulgate had been issued by the end of the 15th century. The Italian Bible was printed a dozen times before 1500, and eighteen editions of the German Bible had already been published before Martin Luther‘s version appeared. From mediaeval time and then again accompanying the Protestant Reformation, there was a marked increase in interest in the scriptures. Notwithstanding the oppositional attitude adopted by the Roman Catholic Church at and after the Council of Trent (1545-1563), the translation and circulation of the Bible were undertaken with greater zeal, and in a more systematic fashion.